Traffic was being diverted after a road accident in Burgess Hill this morning (Friday) in which two people suffered serious injuries.
The A273 Sussex Way was closed to traffic from just before 8am until after 9.30am while emergency services attended to the victims and their cars were removed from the carriageway.
Both drivers had to be released from their vehicles by West Sussex Fire and Rescue Service.
Two rescue service crews were sent from Burgess Hill and the Heavy Rescue Tender from Crawley.
The victims, both men, are believed to have suffered serious but not life-changing injuries.
They were taken to the Royal Sussex Hospital in Brighton by road ambulance.
Paramedics and a doctor were in attendance at the scene as well as the rescue service and police.
The two cars involved were removed around 9.40am and Sussex Road, which feeds into Jane Murray Way, is believed to have reopened now.